PXD067138 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | GNL3 orchestrates AR transcriptional programs to drive castration-resistant prostate cancer and immune evasion |
| Description | Androgen receptor (AR) signaling is a primary oncogenic driver of castration-resistant prostate cancer (CRPC), yet the mechanism remains incompletely understood. Dysregulation of the AR co-regulatory network has emerged as a key driver of castration resistance. To identify AR-interacting proteins linked to CRPC progression, we performed proteomics-based rapid immunoprecipitation of endogenous proteins (RIME) analysis targeting AR in the CRPC cell line C4-2B. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-08 |
| AnnouncementXML | Submission_2026-06-07_16:21:52.960.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Cuiting Zhang |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-08-08 18:43:08 | ID requested | |
| ⏵ 1 | 2026-06-07 16:21:53 | announced | |
Publication List
| 10.1002/advs.202516411; |
| Zhang C, Cheong TL, Narwade N, Dong D, Deng M, Miao Z, Ding Z, Li W, Lei KMK, Wei GH, Poon TCW, Deng CX, Cheung E, GNL3 Orchestrates AR Transcriptional Programs to Drive Castration-Resistant Prostate Cancer and Immune Evasion. Adv Sci (Weinh), 13(26):e16411(2026) [pubmed] |
Keyword List
| submitter keyword: castration-resistant prostate cancer, AR coregulator, immunosuppression,GNL3 |
Contact List
| Edwin Cheung |
|---|
| contact affiliation | Faculty of Health Sciences, University of Macau, Taipa, Macau, China |
| contact email | echeung@um.edu.mo |
| lab head | |
| Cuiting Zhang |
|---|
| contact affiliation | University of Macau |
| contact email | cuiting-zhang@outlook.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD067138 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD067138
- Label: PRIDE project
- Name: GNL3 orchestrates AR transcriptional programs to drive castration-resistant prostate cancer and immune evasion
