PXD067096

PXD067096 is an original dataset announced via ProteomeXchange.

Title	Targeting inflammation and metabolism in hypertrophic cardiomyopathy
Description	Hypertrophic cardiomyopathy (HCM) caused by autosomal-dominant mutations in genes that code for the structural proteins of the sarcomere, is the most common inherited heart disease. HCM is associated with progressive myocardial hypertrophy and fibrosis, ventricular dysfunction, and arrhythmias. Disease onset during childhood and adolescence carries the risk of morbidity and sudden cardiac death. This study evaluates the impact of the R-enantiomer of pioglitazone on the proteome of myocardial tissue using the α-MHC719/+ HCM mouse model.
HostingRepository	PRIDE
AnnounceDate	2026-06-29
AnnouncementXML	Submission_2026-06-28_17:19:27.561.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thomas Fröhlich
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-07 13:40:30	ID requested
⏵ 1	2026-06-28 17:19:28	announced

10.1016/j.jacbts.2026.101574;

Pfaller AT, Veneziano C, Murthi SR, St, ö, ckl JB, Shashikadze B, Flenkenthaler F, Gorham J, Moretti A, Kitanovic A, Gearing LJ, Heinrich F, Durek P, Lehmann K, Mashreghi MF, Ewert P, Fr, ö, hlich T, Schmitt JP, Spielmann N, Hrab, ě, de Angelis M, Schmid M, Toepfer CN, Latz E, Klingel K, Santamaria G, Seidman JG, Seidman CE, Wolf CM, Targeting Inflammation by Pioglitazone and its R-Enantiomer Mitigates Pathological Myocardial Remodeling in Murine Hypertrophic Cardiomyopathy. JACC Basic Transl Sci, 11(7):101574(2026) [pubmed]

submitter keyword: pioglitazone,Hypertrophic cardiomyopathy, myocardial hypertrophy

Thomas Fröhlich
contact affiliation	Ludwig-Maximilians-Universität München Genzentrum Laboratory for Functional Genome Analysis Feodor-Lynen-Str. 25 D-81377 München
contact email	frohlich@genzentrum.lmu.de
lab head
Thomas Fröhlich
contact affiliation	Ludwig-Maximilians-Universität München Genzentrum Laboratory for Functional Genome Analysis Feodor-Lynen-Str. 25 81377 Munich
contact email	frohlich@genzentrum.lmu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD067096

PRIDE project URI

• PRIDE
  1. PXD067096
     1. Label: PRIDE project
     2. Name: Targeting inflammation and metabolism in hypertrophic cardiomyopathy