PXD067027

PXD067027 is an original dataset announced via ProteomeXchange.

Title	Integrated Multi-Omics Analysis of Dampness-Heat Gout Reveals Diagnostic Biomarkers and Therapeutic Targets
Description	Damp-heat gout (DHG) is a clinically recognized subtype of gout characterized by a specific syndrome in traditional Chinese medicine (TCM). However, its pathomechanism remains unclear, and there is a lack of quantifiable indicators for accurate clinical diagnosis and treatment. This study aimed to elucidate the pathological mechanisms underlying DHG and to establish a symptom-centered model for its diagnosis and treatment. A total of 136 participants, comprising healthy controls and diagnosed DHG patients, were recruited for the analysis. Utilizing serum metabolomics and proteomics methodologies, we identified 21 common pathways associated with DHG, highlighting four crucial pathways: bile secretion, cholesterol metabolism, purine metabolism, and arachidonic acid metabolism, which were found to correlate significantly with the primary symptoms of DHG. Additionally, six key biomarkers—hypoxanthine, prostaglandin E2, uric acid, deoxycholic acid, taurochenodeoxycholic acid, and bilirubin—were identified. These biomarkers demonstrated robust diagnostic potential, with AUC values of 0.987 in the discovery cohort and above 0.99 in the validation cohort. Furthermore, six potential protein therapeutic targets were identified, including ATP1A1, APRT, ANGPTL4, GLUT1, PTGES3, and LIPA. In conclusion, our study establishes a symptom-centered diagnostic and therapeutic model for DHG based on identified biomarkers. It also clarifies key metabolic pathways involved, paving the way for improved diagnosis and targeted treatment strategies in clinical management.
HostingRepository	iProX
AnnounceDate	2025-08-07
AnnouncementXML	Submission_2025-08-06_20:33:58.274.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Le Yang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-06 20:33:37	ID requested
⏵ 1	2025-08-06 20:33:58	announced

Dataset with its publication pending

submitter keyword: Dampness-Heat gout, Multi-Omics, LC-MS/MS, DIA dataset

Xijun Wang
contact affiliation	The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
contact email	xijunw@sina.com
lab head
Le Yang
contact affiliation	The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
contact email	leyang92gzy@sina.com
dataset submitter

iProX dataset URI