PXD067025
PXD067025 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Chromatin Remodeler RSF1 as an Oncogenic Driver and Therapeutic Target in Esophageal Squamous Cell Carcinoma |
| Description | Esophageal squamous cell carcinoma (ESCC) is a prevalent malignancy, ranking eleventh in inci-dence and seventh in mortality globally. Remodeling and Spacing factor 1 (RSF1), a chromatin remodeling factor, is frequently overexpressed in various tumors and correlates with poor prog-nosis. This study, combining public database analysis and clinical sample validation, reveals sig-nificantly elevated RSF1 expression in ESCC tumor tissues, confirmed further in an ESCC orthotopic model. Functional assays show that RSF1 knockout (KO) significantly inhibits ESCC cell proliferation, migration, invasion, and in vivo tumor growth, while reintroducing RSF1 restores its oncogenic effects. Proteomic analysis highlight RSF1 KO disrupts pathways associated with cell cycle control, apoptosis, and focal adhesion. Experimentally, RSF1 KO induces apoptosis and G2/M arrest, estab-lishing its essential role in ESCC progression. Collectively, these findings establish RSF1 an oncogenic driver and a promising therapeutic target in ESCC |
| HostingRepository | iProX |
| AnnounceDate | 2025-08-07 |
| AnnouncementXML | Submission_2025-08-06_20:31:40.862.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhenhua Du |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-08-06 20:30:28 | ID requested | |
| ⏵ 1 | 2025-08-06 20:31:41 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: RSF1, esophageal squamous cell carcinoma, cell cycle, apoptosis |
Contact List
| Hengbin Wang | |
|---|---|
| contact affiliation | Department of Internal Medicine, Division of Hematology, Oncology and Palliative Care, Massey Comprehensive Cancer Center |
| contact email | hengbin.wang@vcuhealth.org |
| lab head | |
| Zhenhua Du | |
| contact affiliation | Henan University |
| contact email | hzdw0324@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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