⮝ Full datasets listing
PXD066968
PXD066968 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | shCTRL and shOrai1, IFN-γ 6 hr |
| Description | We investigated whether store-operated Ca²⺠entry (SOCE) contributes to PD-L1 regulation in oral squamous cell carcinoma (OSCC) cells. Proteomic analysis revealed IFN-γ stimulation activates calcium-related signaling. Pharmacological SOCE inhibition with Synta66 suppressed IFN-γ-induced PD-L1 protein expression dose-dependently. Knockdown of Orai1 or STIM1 had no effect under basal conditions but significantly reduced PD-L1 induction under IFN-γ stimulation. Inhibition of CaMKII and CaMKKII also suppressed PD-L1 expression at both mRNA and protein levels. Furthermore, Orai1 or STIM1 knockdown OSCC cells exhibited reduced proliferation when co-cultured with CD8⺠T cells, suggesting SOCE inhibition enhances immune-mediated tumor suppression. |
| HostingRepository | jPOST |
| AnnounceDate | 2026-08-05 |
| AnnouncementXML | Submission_2026-08-04_08:00:05.099.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Eriko Yamashita |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | unknown modification; alpha-amino acetylated residue; S-carboxamidomethyl-L-cysteine; alpha-aminocarbamoylated residue; L-methionine sulfoxide |
| Instrument | instrument |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-08-05 01:11:04 | ID requested | |
| ⏵ 1 | 2026-08-04 08:00:05 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: oral cancer |
Contact List
| Masanari Umemura | |
|---|---|
| lab head | |
| Eriko Yamashita | |
| contact affiliation | Yokohama city University |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003984/ |
