PXD066946

PXD066946 is an original dataset announced via ProteomeXchange.

Title	Proteomic sex determination vs osteological sex estimation – what effect do our techniques have on the way we view the people of the past?
Description	Amelogenin, a protein involved in the formation of enamel occurs as two isoforms, AMEL X and AMEL Y, which are encoded on the X and Y chromosome respectively. Isoform-specific peptides can be used for the determination of the chromosomal sex in ancient teeth. This strategy was used to determine the chromosomal sex of individuals from tooth material of historic New Zealand cemetery samples by mass spectrometry-based amelogenin peptide analysis. We show what can happen when osteobiographies are constructed for individuals for whom osteological sex estimation was inaccurate. We also highlight the uses of peptide analysis in identifying individuals, particularly non-adults for whom osteological sex estimation is not possible. Peptide analysis of historic New Zealand cemetery samples has helped to change our interpretations and added to our understanding of these populations.
HostingRepository	PRIDE
AnnounceDate	2025-11-25
AnnouncementXML	Submission_2025-11-25_11:54:33.305.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Torsten Kleffmann
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-04 13:00:09	ID requested
⏵ 1	2025-11-25 11:54:33	announced

10.1002/AJPA.70170;

submitter keyword: chromosomal sex determination, AMEL Y, AMEL X,Amelogenin

Charlotte King
contact affiliation	Department of Anatomy, University of Otago, New Zealand
contact email	charlotte.king@otago.ac.nz
lab head
Torsten Kleffmann
contact affiliation	Department of Biochemistry, University of Otago
contact email	torsten.kleffmann@otago.ac.nz
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD066946

PRIDE project URI

• PRIDE
  1. PXD066946
     1. Label: PRIDE project
     2. Name: Proteomic sex determination vs osteological sex estimation – what effect do our techniques have on the way we view the people of the past?