PXD066917
PXD066917 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Site-specific Profiling of RNA-binding Proteins Enabled by Isotopic Signature Enhanced Mass Spectrometry |
| Description | We developed an innovative method named “isoRIC” for profiling RNA-binding proteomes with site-specific resolution, which combined the metabolic labeling of isotopic nucleotides for photo-crosslinking of RNA-binding proteins and the real-time targeted LC-MS/MS analysis of RNA-crosslinked peptides. This method showed dramatic improvement of sensitivity in identifying RNA-crosslinked peptides with low abundance as compared to the DDA-based proteomic approaches, which enables the discovery of novel RNA-binding proteins and precise mapping of RNA-protein binding interfaces at single amino acid resolution. |
| HostingRepository | iProX |
| AnnounceDate | 2025-08-04 |
| AnnouncementXML | Submission_2025-08-04_01:09:00.616.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yicheng Liu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-08-04 01:08:30 | ID requested | |
| ⏵ 1 | 2025-08-04 01:09:00 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: RNA binding protein, RNA crosslinked site |
Contact List
| Chu Wang | |
|---|---|
| contact affiliation | Peking University |
| contact email | chuwang@pku.edu.cn |
| lab head | |
| Yicheng Liu | |
| contact affiliation | Peking University |
| contact email | ycliu2055@outlook.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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