PXD066907
PXD066907 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic Signature of Aging in Bloodstain Samples: A Preliminary Study |
| Description | Age estimation from biological samples remains a critical challenge in forensic investigations, particularly when analyzing trace or degraded biological stains recovered from crime scenes. While DNA methylation has gained attention as a potential epigenetic clock for age prediction, practical limitations including the requirements for bisulfite conversion and environmental interference hinder its forensic utility. Previous studies have shown that proteins are more stable than DNA and that certain proteins are highly age-related and sex-differentiated, indicating that proteomic signatures present a promising alternative for biological age determination. However, proteomic data from bloodstains have not yet been used for forensic age prediction. In this pilot study, we used the high-resolution Thermo Scientific Orbitrap Astral mass spectrometer to investigate the proteomic signatures of aging in bloodstain samples from 40 healthy males (aged 10–79 years) stored for 4 years at room temperature (20 – 25°C). Age-related proteins were subsequently selected for age prediction. We further simplified the characterization variables using Lasso regression and the Boruta algorithm, and established age prediction models for bloodstains based on Random Forest machine learning. |
| HostingRepository | iProX |
| AnnounceDate | 2025-08-03 |
| AnnouncementXML | Submission_2025-08-03_23:18:01.152.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Niu Gao |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-08-03 23:16:19 | ID requested | |
| ⏵ 1 | 2025-08-03 23:18:01 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Age prediction, Bloodstain, Orbitrap astral, Proteomics |
Contact List
| Jiangwei Yan | |
|---|---|
| contact affiliation | School of Forensic Medicine, Shanxi Medical University |
| contact email | yanjiangwei@gmail.com |
| lab head | |
| Niu Gao | |
| contact affiliation | School of Forensic Medicine, Shanxi Medical University |
| contact email | Gaoniu1356@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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