PXD066811 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Tandem Mass Tag-Based Quantitative Proteomics of Extracellular Vesicles Isolated from Mammary Fibroblasts Treated with γ-radiation |
| Description | Small extracellular vesicles (EVs) were isolated from a model of normal breast fibroblasts— immortalized cells derived from healthy reduction mammoplasty tissue—treated with γ-radiation to study the effects of radiation therapy on intercellular communication within the breast stroma. EVs were isolated using the gold-standard differential speed centrifugation protocol. Proteins were extracted and analyzed using a TMT-based quantitative proteomics approach. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-01 |
| AnnouncementXML | Submission_2026-05-31_16:15:36.191.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Kristie Lindsey Rose |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-07-31 10:06:24 | ID requested | |
| ⏵ 1 | 2026-05-31 16:15:37 | announced | |
Publication List
| Berumen S, á, nchez G, Patel P, Gomez-Crase P, Kim C, Corn KC, Rose KL, Rafat M, Mammary Fibroblasts Secrete Damage Associated Molecular Patterns Through Extracellular Vesicles in Response to Ionizing Radiation. J Extracell Biol, 5():e70147(2026) [pubmed] |
| 10.1002/jex2.70147; |
Keyword List
| submitter keyword: proteomics,extracellular vesicles, TMT-based quantification, ionizing radiation |
Contact List
| Kristie Lindsey Rose |
|---|
| contact affiliation | Vanderbilt University Proteomics Core |
| contact email | kristie.rose@vanderbilt.edu |
| lab head | |
| Kristie Lindsey Rose |
|---|
| contact affiliation | Vanderbilt University |
| contact email | kristie.rose@vanderbilt.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD066811 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD066811
- Label: PRIDE project
- Name: Tandem Mass Tag-Based Quantitative Proteomics of Extracellular Vesicles Isolated from Mammary Fibroblasts Treated with γ-radiation
