PXD066801

PXD066801 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Phosphorylation of LARS (leucyl-tRNA synthetase) induced by amino acid stimulation
Description	LARS undergoes structural changes in response to amino acid stimulation and translocates to lysosome, exhibiting non-canonical functions such as mTORC1 activation instead of its canonical function of tRNA amino-acylation. This study investigates which post-translational modifications (PTMs) of LARS occur during amino acid stimulation and how these modifications affect the non-canonical functions of LARS. We identified phosphorylation occurring at LARS residues S1070, S1077, and S1082.
HostingRepository	PRIDE
AnnounceDate	2026-04-06
AnnouncementXML	Submission_2026-04-05_16:21:03.921.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD066801
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	YOUJIN KIM
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	phosphorylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Eclipse

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-31 07:00:03	ID requested
⏵ 1	2026-04-05 16:21:04	announced

Publication List

10.6019/PXD066801;

10.6019/PXD066801;

Keyword List

submitter keyword: None

submitter keyword: None

Contact List

Hee-Sung Park
contact affiliation	Department of Chemistry, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea
contact email	hspark@kaist.ac.kr
lab head
YOUJIN KIM
contact affiliation	Korea Advanced Institute of Science and Technology
contact email	barca2625@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD066801
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD066801

PRIDE project URI

Repository Record List

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