PXD066757 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Suboptimal codon pairs trigger ribosome collisions and cellular quality control responses in tRNA modification mutants |
| Description | Validation of activation of RQC in U34 tRNA modification mutants by identification of ubiquitination of ribosomal proteins uS3 and uS10. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-29 |
| AnnouncementXML | Submission_2025-12-28_16:52:14.046.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Manfred Heller |
| SpeciesList | scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: NEWT:4932; |
| ModificationList | ubiquitination signature dipeptidyl lysine; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-07-30 06:17:34 | ID requested | |
| ⏵ 1 | 2025-12-28 16:52:15 | announced | |
Publication List
| Wu J, Eggers C, Sin O, Koziej Ł, Mancilla H, Mollet F, Sch, ö, ler HR, Drexler HCA, Ranff T, Fufezan C, Kraft C, Glatt S, Bruder JM, Leidel SA, Suboptimal codon pairs trigger ribosome collisions and cellular quality control responses in tRNA modification mutants. Nucleic Acids Res, 53(22):(2025) [pubmed] |
| 10.1093/nar/gkaf1311; |
Keyword List
| submitter keyword: tRNA modification |
| ribosome profiling |
| protein aggregates |
| protein homeostasis |
| ribosome-associated quality control |
| chaperones |
| integrated stress response |
| mRNA translation |
| codon pairs |
| codon optimality |
Contact List
| Sebastian Leidel |
|---|
| contact affiliation | Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern |
| contact email | sebastian.leidel@unibe.ch |
| lab head | |
| Manfred Heller |
|---|
| contact affiliation | Proteomics and Mass Spectrometry Core Facility,
Departement for Biomedical Research,
University of Berne |
| contact email | pmscf.dbmr@unibe.ch |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD066757 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD066757
- Label: PRIDE project
- Name: Suboptimal codon pairs trigger ribosome collisions and cellular quality control responses in tRNA modification mutants
