PXD066660

PXD066660 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Myeloid cell-mediated killing of BCP-ALL by IgA2 variants of CD38 or CD20 antibodies is enhanced by CD47/SIRPα interference
Description	Characterization of therapeutic monoclonal antibodies used in the context of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). IgA2 antibodies targeting CD38 were analyzed using LC-MS/MS. Mass analysis, peptide mapping and glycoprofiling were performed to confirm sequence integrity and post-translational modifications. The analysis supports preclinical evaluation of antibody-based immunotherapies and provides insights into glycosylation relevant for effector function.
HostingRepository	PRIDE
AnnounceDate	2026-06-09
AnnouncementXML	Submission_2026-06-08_21:35:09.422.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Arturo Macarron Palacios
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	6545 Q-TOF LC/MS

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-28 06:18:47	ID requested
⏵ 1	2026-06-08 21:35:09	announced

Publication List

10.1016/J.BNEO.2026.100242;

10.1016/J.BNEO.2026.100242;

Keyword List

submitter keyword: peptide mapping, LC-MS, glycoprofiling,Daratumomab-IgA

submitter keyword: peptide mapping, LC-MS, glycoprofiling,Daratumomab-IgA

Contact List

Arturo Macarrón Palacios
contact affiliation	GenCC GmbH & Co. KG, Germany
contact email	arturo.macarron@gencc.eu
lab head
Arturo Macarron Palacios
contact affiliation	GenCC GmbH & Co. KG
contact email	arturo.macarron@gencc.eu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD066660
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD066660

PRIDE project URI

Repository Record List

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