PXD066590

PXD066590 is an original dataset announced via ProteomeXchange.

Title	Integrated landscape of renal metabolism in domestic cats with spontaneous chronic kidney disease: a multi-omics study
Description	Chronic kidney disease (CKD) is the leading cause of mortality in aged cats. After injury, feline kidneys undergo extensive metabolic reprogramming, but a comprehensive evaluation is lacking. Integration of serum metabolome from early stages, late stages CKD and healthy control cats with renal cortex and medulla transcriptome and proteome can reveal spatiotemporal patterns of gene and protein expression changes. In this study, we conducted mass spectrometry (MS)-based proteomic analysis of kidney (cortex and medulla) tissues from cats with CKD and control cats, euthanized for humane reasons unrelated to the study.
HostingRepository	PRIDE
AnnounceDate	2025-10-14
AnnouncementXML	Submission_2025-10-14_09:28:56.300.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Loïc Dayon
SpeciesList	scientific name: Felis catus (Cat) (Felis silvestris catus); NCBI TaxID: NEWT:9685;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-25 05:36:18	ID requested
⏵ 1	2025-10-14 09:28:56	announced

Dataset with its publication pending

submitter keyword: LC-MSMS, Disease, Kidney,Cat

Loïc Dayon
contact affiliation	Nestlé Research – Nestlé Institute of Food Safety & Analytical Sciences
contact email	loic.dayon@rd.nestle.com
lab head
Loïc Dayon
contact affiliation	Nestlé Research – Nestlé Institute of Food Safety & Analytical Sciences
contact email	loic.dayon@rd.nestle.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD066590

PRIDE project URI

• PRIDE
  1. PXD066590
     1. Label: PRIDE project
     2. Name: Integrated landscape of renal metabolism in domestic cats with spontaneous chronic kidney disease: a multi-omics study