PXD066537

PXD066537 is an original dataset announced via ProteomeXchange.

Title	Influence of temporal interference electrical stimulation on protein expression in the dentate gyrus of APPN-L-GF mouse models
Description	Adult hippocampal neurogenesis is involved in key cognitive phenomena, such as memory and learning, mood regulation, stress and anxiety. In postmortem human patients, adult neurogenesis has been shown to decrease in correlation with Alzheimer’s disease and mild cognitive decline. Thus, therapies aiming to restore neurogenesis and neural differentiation in the hippocampus are currently emerging. Electrical stimulation has been shown to modulate the proliferation and differentiation of neural progenitor cells (NPCs). Although stimulation therapies such as deep brain stimulation (DBS) have been widely used in the clinic, their invasiveness hinders regenerative medicine applications. DBS via temporally interfering (TI) electric fields has emerged as a promising strategy for non-invasive deep brain stimulation (Grossman et al., 2017). We previously demonstrated via immunohistochemistry that TI stimulation at the theta frequency for 8 days, 1h/day, increases differentiation (doublecortin) and proliferation (ki67) in the right dentate gyrus of 6-7 months old APPN-L-GF mouse models. Here, we investigate potential mechanisms of such neurogenic effect via bulk proteomics in the ipsilateral dentate gyrus of TI-stimulated and sham mice. We report an increased expression of chemical synaptic transmission pathways, mRNA metabolism and the MAPK/ERK cascade (among others) in the TI-stimulated mice compared to sham.
HostingRepository	PRIDE
AnnounceDate	2026-09-07
AnnouncementXML	Submission_2026-09-06_16:29:17.363.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bethany Geary
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Bruker Daltonics instrument model

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-24 07:57:33	ID requested
⏵ 1	2026-09-06 16:29:18	announced

10.1002/advs.202524341;

Peressotti S, Garcia Garrido M, Dzialecka P, Hoi Law RM, Portillo-Lara R, Geary B, Faillace E, Merlo-Nikpay Aslie S, Wojewska M, Otero-Jimenez M, Genta M, Tan L, Duff K, Alegre-Abarrategui J, Green R, Grossmann N, Temporal Interference Stimulation Enhances Neural Regeneration. Adv Sci (Weinh), 13(37):e24341(2026) [pubmed]

submitter keyword: NPCs,Alzheimers, mouse, dentate gyrus, APP

Nir Grossman
contact affiliation	UK Dementia Research Institute Imperial College London
contact email	nirg@imperial.ac.uk
lab head
Bethany Geary
contact affiliation	UK Dementia Research Institute
contact email	beth.geary@ukdri.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD066537
     1. Label: PRIDE project
     2. Name: Influence of temporal interference electrical stimulation on protein expression in the dentate gyrus of APPN-L-GF mouse models