PXD066521
PXD066521 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Time-Series Multi-Omics Identifies ZG16 as a Prognostic Immunoregulatory Driver of Colitis-associated Colon Cancer Development and Checkpoint Blockade Response |
| Description | This dataset contains quantitative proteomic profiles across five disease stages (W0, W2, W5, W8, W11) of colitis-associated colorectal cancer (CAC) using a mouse AOM/DSS model. Proteins were extracted from tumor tissues and processed for LC-MS/MS after labeling with iTRAQ 6-plex reagents. The goal was to identify temporal dynamics of protein expression underlying chronic inflammation-induced tumorigenesis. |
| HostingRepository | iProX |
| AnnounceDate | 2025-07-24 |
| AnnouncementXML | Submission_2025-07-24_03:08:02.478.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Lu Chen |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | TripleTOF 5600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-07-24 03:07:47 | ID requested | |
| ⏵ 1 | 2025-07-24 03:08:02 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Colitis-associated colorectal cancer |
| Immune checkpoint therapy |
| Tumor microenvironment |
| ZG16 |
| Time-series multi-omics |
| PD-L1 regulation |
| CD8+ T cells |
Contact List
| Yang Zhang | |
|---|---|
| contact affiliation | Fudan university |
| contact email | zhangyang@fudan.edu.cn |
| lab head | |
| Lu Chen | |
| contact affiliation | Shanghai Cancer Center, Fudan University |
| contact email | vic198987@gmail.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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