PXD066515

PXD066515 is an original dataset announced via ProteomeXchange.

Title	An integrative proteomic approach during Alzheimer’s disease progression in Tau PS19 mice
Description	Alzheimer's disease (AD) is a slowly progressive neurodegenerative disease associated with cognitive, functional, and behavioral impairments characterized by the progressive accumulation of extracellular amyloid-beta plaques and intracellular neurofibrillary tangles of hyperphosphorylated tau protein. AD is associated with the dysfunction of several essential neurotransmitter systems, such as dopamine, and individuals with AD have been shown to have impaired neurotransmission. Although neurotransmitter changes in the brain are associated with AD pathology, in-depth profiling studies on neurotransmitters and their related proteomic changes need to be conducted. Thus, we conducted a study to profile and integrate the proteomes and neurotransmitters in seven brain regions of PS19 (Tau P301S) mice according to AD progression between 4-month and 7-month. Proteomic analysis revealed significantly altered canonical pathways in various brain regions, including metabolic abnormalities. In the neurotransmitter profile, we found that six neurotransmitters, dopamine, serotonin, homovanillic acid, norepinephrine, 3-methoxytyramine, and 3,4-dihydroxyphenylacetic acid, were significantly altered during AD progression. Using an integrative approach between proteome and neurotransmitter profiles, we found that AD progression-dependent dopamine- and serotonin-related signaling modules are closely related to neurotransmitter changes, especially in the hippocampus and cerebellum. This integrative approach could provide new signaling modules to help understand the progression of AD.
HostingRepository	PRIDE
AnnounceDate	2026-06-15
AnnouncementXML	Submission_2026-06-14_19:22:04.884.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD066515
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Eunji Cho
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	methylthiolated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-24 02:23:19	ID requested
⏵ 1	2026-06-14 19:22:05	announced

10.1016/j.mcpro.2026.101580;

10.6019/PXD066515;

Cho E, Lee S, Lee H, Kim J, Kwon YW, Hoe HS, Kim D, Yoon JH, An Integrative Proteomic Approach to Reveal Altered Signaling Modules During Alzheimer's Disease Progression in PS19 Tauopathy Mice. Mol Cell Proteomics, 25(6):101580(2026) [pubmed]

submitter keyword: None

Jong Hyuk Yoon
contact affiliation	Neurodegenerative Diseases Research Group, Korea Brain Research Institute, Daegu 41062, Republic of Korea
contact email	jhyoon@kbri.re.kr
lab head
Eunji Cho
contact affiliation	Korea Brain Research Institute
contact email	prettybox5@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD066515
     1. Label: PRIDE project
     2. Name: An integrative proteomic approach during Alzheimer’s disease progression in Tau PS19 mice