PXD066511

PXD066511 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of the thryoid eye disease tear film
Description	Thyroid eye disease (TED) is a complex autoimmune disease that is often disfiguring and sight threatening. Recent advances have shifted the treatment paradigm from traditional immunosuppressive therapies such as corticosteroids to targeted biologic agents, such as teprotumumab (TMB; anti-IGF-1R) which has been demonstrated to improve proptosis, diplopia, and inflammatory signs in TED patients. In patients with limited response to teprotumumab, developing new drug targets or repositioning already-approved drugs can bring effective, alternative options. To identify new drug targets for TED, we quantified protein expression in living patients using a non-invasive testing method. Tear fluid samples were collected using Schirmer strips from two groups: control patients without ocular surface disease (n = 30) and TED patients before and after treatment with TMB (n = 22). Proteins were extracted from Schirmer strips and underwent proteomic analysis.
HostingRepository	PRIDE
AnnounceDate	2026-06-08
AnnouncementXML	Submission_2026-06-08_11:40:12.689.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD066511
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Gabriel Velez
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-24 00:56:14	ID requested
⏵ 1	2026-06-08 11:40:13	announced

10.6019/PXD066511;

submitter keyword: Thyroid eye disease, Teprotumumab, tears, TED

Vinit Mahajan
contact affiliation	Byers Eye Institute, Stanford University
contact email	vinit.mahajan@stanford.edu
lab head
Gabriel Velez
contact affiliation	Byers Eye Institute, Stanford Univeristy
contact email	gvelz@stanford.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD066511

PRIDE project URI

• PRIDE
  1. PXD066511
     1. Label: PRIDE project
     2. Name: Proteomic analysis of the thryoid eye disease tear film