PXD066491

PXD066491 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Profiling of tumor-derived extracellular vesicles secreted by genetically MC38 modified cells
Description	In this study exosomal vesicle protein content of genetically modified mouse MC38 colorectal cell lines was assessed. The genetic modifications included overexpression of IL18 and shRNA silencing of IL-10 or TGF-β in following combinations: IL18 overexpression, IL10 silencing, IL10 silencing and IL18 overexpression, TGF-β silencing, TGF-β silencing and IL18 overexpression. All lines were assessed via LFQ bottom-up proteomics relative to a WT control.
HostingRepository	PRIDE
AnnounceDate	2026-03-05
AnnouncementXML	Submission_2026-03-05_12:50:30.368.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD066491
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Michał Tracz
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	Synapt MS

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-23 14:59:13	ID requested
⏵ 1	2026-03-05 12:50:30	announced

Publication List

10.1016/J.JCONREL.2026.114771;
10.6019/PXD066491;

10.1016/J.JCONREL.2026.114771;

10.6019/PXD066491;

Keyword List

submitter keyword: extracellular vesicles LFQ proteomics mTEVs EVs DCs dendritic cells MC38 TGFB1 IL18 IL10

submitter keyword: extracellular vesicles LFQ proteomics mTEVs EVs DCs dendritic cells MC38 TGFB1 IL18 IL10

Contact List

Michał Tracz
contact affiliation	Laboratory of Mass Spectrometry, Faculty of Biotechnology, University of Wroclaw
contact email	michal.tracz2@uwr.edu.pl
lab head
Michał Tracz
contact affiliation	Laboratory of Mass Spectrometry, Faculty of Biotechnology, University of Wroclaw
contact email	michal.tracz2@uwr.edu.pl
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD066491
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD066491

PRIDE project URI

Repository Record List

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