⮝ Full datasets listing
PXD066468
PXD066468 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Characterization of a GpsB-associated regulator of PBP1a reveals the organization of the cell wall remodeling complex of Streptococcus pneumoniae |
| Description | Class A PBPs (aPBPs) play a key role in the biosynthesis and remodeling of peptidoglycan, the main component of the bacterial cell wall. The human bacterial pathogen Streptococcus pneumoniae produces three aPBPs, which are regulated to maintain the ovoid shape of the bacterium. Although their exact functions remain unclear, evidence suggests that PBP1a and PBP2a activities are closely coordinated. In this study, we elucidated the function of an unknown function protein named GarP (GpsB-associated regulator of PBP1a), in the regulation of PBP1a activity. We showed that GarP localizes to the division septum and its absence leads to morphological defects. We further identified a GpsB-binding motif in GarP as well as in PBP2a, the PG deacetylase PgdA and the muramidase MpgA. Our analysis of genetic and protein interactions, combined with cell imaging, supports a model of a molecular complex that coordinates PG remodeling during S. pneumoniae cell division. |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-10-24 |
| AnnouncementXML | Submission_2025-10-24_08:12:18.009.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | DELOLME |
| SpeciesList | scientific name: Streptococcus pneumoniae; NCBI TaxID: 1313; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-07-23 06:02:34 | ID requested | |
| ⏵ 1 | 2025-10-24 08:12:18 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: peptidoglycan, cell wall, Streptococcus pneumoniae, cell division and morphogenesis, penicillin-binding proteins, DatasetType:Proteomics |
Contact List
| Christophe GRANGEASSE | |
|---|---|
| contact affiliation | MMSB-UMR5086-CNRS |
| contact email | christophe.grangeasse@cnrs.fr |
| lab head | |
| DELOLME | |
| contact affiliation | CNRS |
| contact email | frederic.delolme@ibcp.fr |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v10/MSV000098614/ |
