PXD066461

PXD066461 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Post-Translational Modification Analysis in TCR Complexes Using Mass Spectrometry
Description	This study investigates the structural and biochemical characteristics of T cell receptors (TCRs) involved in immune recognition. Using mass spectrometry-based proteomics, we analyzed post-translational modifications (PTMs), including glycosylation patterns, of different TCR variants. These modifications provide insight into the molecular regulation of TCR function and their interaction with peptide-MHC complexes. Complementary biophysical analyses, such as mass photometry, were performed to understand the oligomeric states of TCR-pMHC complexes. The findings contribute to a deeper understanding of TCR regulation and immune signaling mechanisms.
HostingRepository	PRIDE
AnnounceDate	2025-08-07
AnnouncementXML	Submission_2025-08-07_04:20:16.129.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD066461
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	CANER AKIL
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	complex glycosylation
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-23 03:41:19	ID requested
⏵ 1	2025-08-07 04:20:16	announced

Publication List

10.6019/PXD066461;

10.6019/PXD066461;

Keyword List

submitter keyword: glycosylation,T cell receptor

submitter keyword: glycosylation,T cell receptor

Contact List

DR CANER AKIL
contact affiliation	UNIVERSITY OF OXFORD, DIVISION OF STRUCTURAL BIOLOGY
contact email	caner.akil@strubi.ox.ac.uk
lab head
CANER AKIL
contact affiliation	UNIVERSITY OF OXFORD
contact email	caner.akil@strubi.ox.ac.uk
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD066461

PRIDE project URI

Repository Record List

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