PXD066450

PXD066450 is an original dataset announced via ProteomeXchange.

Title	RPL3L Mutant Heart Cells LFQ MS.
Description	Mutations in the tissue-specific ribosomal protein RPL3L lead to infant dilated cardiomyopathy. The current project aims to understand the mechanistic details of disease progression using in vivo biopsies from transplanted heart of patient with RPL3L mutations as well as engineered AC16 cell lines that express the same and other RPL3L variants containing a C-terminal HA tag. The files consist of two datasets from human left ventricle (LV) and human AC16 cells, respectively. The human LV samples are two technical replicates from the same biopsy. The AC16 cell samples are immunoprecipitations of HA-tagged RPL3L in nuclear extracts.
HostingRepository	PRIDE
AnnounceDate	2025-11-15
AnnouncementXML	Submission_2025-11-15_11:17:37.659.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rajesh Soni
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro 2

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-23 02:26:06	ID requested
⏵ 1	2025-11-15 11:17:38	announced

Dataset with its publication pending

submitter keyword: Ribosome,Cardiomyopathy, AC16, Ventricle

Xuebing Wu
contact affiliation	Assistant Professor Department of Medicine | Cardiology | Cardiometabolic Precision Medicine Program Department of Systems Biology Herbert Irving Comprehensive Cancer Center | Precision Oncology and Systems Biology Program Data Science Institute | Health Analytics Center Columbia Stem Cell Initiative Columbia University Irving Medical Center 630 West 168th Street, P&S 10-401, New York, NY 10032
contact email	xw2629@cumc.columbia.edu
lab head
Rajesh Soni
contact affiliation	Columbia University Medical center
contact email	rs3869@cumc.columbia.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD066450

PRIDE project URI

• PRIDE
  1. PXD066450
     1. Label: PRIDE project
     2. Name: RPL3L Mutant Heart Cells LFQ MS.