PXD066330

PXD066330 is an original dataset announced via ProteomeXchange.

Title	Mechanistic insights into the anticancer effect of pyridopyrimidine derivatives in Gastric Adenocarcinoma
Description	This study presents the design, synthesis, and in vitro evaluation of novel pyridopyrimidine derivatives as potential anticancer agents against gastric cancer. Several compounds showed strong cytotoxic and selective antiproliferative effects in AGS cells. To uncover the mode of action of representative compound, label-free quantitative proteomics was performed, revealing key alterations in proteins linked to various spotted pathways as indicated in IPA analysis.
HostingRepository	jPOST
AnnounceDate	2026-07-20
AnnouncementXML	Submission_2026-07-19_08:00:11.975.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Muhammad Alsherbiny
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; L-methionine sulfoxide
Instrument	TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-19 20:49:30	ID requested
⏵ 1	2026-07-19 08:00:12	announced

Dataset with its publication pending

submitter keyword: AGS cells, Gastic cancer, Pyridopyrimidine, Proteomics

Mohamed Metwaly
lab head
Muhammad Alsherbiny
contact affiliation	Faculty of Pharmacy Cairo University, Victor Chang Cardiac Research Institute
dataset submitter

jPOST dataset URI

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