⮝ Full datasets listing
PXD066329
PXD066329 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Design, synthesis, and biological evaluation of pyridopyrimidine derivatives in gastric cancer cells. |
| Description | This study reports the rational design, synthesis, and in vitro biological evaluation of a novel series of pyridopyrimidine derivatives as potential anticancer agents targeting gastric cancer. The compounds were screened against the AGS gastric adenocarcinoma cell line To investigate the underlying mechanisms of action, a comprehensive label-free quantitative proteomics approach was employed. Differential protein expression analysis revealed key pathways modulated by the lead compound. |
| HostingRepository | jPOST |
| AnnounceDate | 2026-07-20 |
| AnnouncementXML | Submission_2026-07-19_08:00:04.785.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Muhammad Alsherbiny |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | S-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; L-methionine sulfoxide |
| Instrument | TripleTOF 6600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-07-19 20:28:05 | ID requested | |
| ⏵ 1 | 2026-07-19 08:00:05 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: pyridopyrimidine, Proteomics |
Contact List
| Mohamed Metwaly | |
|---|---|
| lab head | |
| Muhammad Alsherbiny | |
| contact affiliation | Faculty of Pharmacy Cairo University, Victor Chang Cardiac Research Institute |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003952/ |
