⮝ Full datasets listing
PXD066299
PXD066299 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Understanding the Mechanisms of Asperidine B, a Preussin Derivative, on the Inhibition of Intestinal Cholesterol Absorption Mediated by Tight Junction Function |
| Description | • Preussin derivatives, asperidine B and its desmethyl analogue, exerted antioxidative and lipid-lowering effects similarly to their parent compound. • Asperidine B had higher potency by lowering cholesterol level than its methyl analogue in both ex vivo isolated jejunal epithelium, and in vivo models. • Asperidine B upregulated α-catenin and EpCAM proteins by proteomics approach, which they are relevance in tight junction integrity. • Asperidine B strongly inhibited intestinal cholesterol absorption by directly interaction with ZO-1 protein function and expression. |
| HostingRepository | jPOST |
| AnnounceDate | 2026-07-18 |
| AnnouncementXML | Submission_2026-07-17_08:00:05.119.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Dr.Wararat Chiangjong |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide |
| Instrument | TripleTOF 5600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-07-17 23:42:43 | ID requested | |
| ⏵ 1 | 2026-07-17 08:00:05 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Preussin derivatives, Lipid lowering, Tight junction, Proteomics |
Contact List
| Chutima S. Vaddhanaphuti | |
|---|---|
| lab head | |
| Dr.Wararat Chiangjong | |
| contact affiliation | Mahidol University |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003949/ |
