PXD066203

PXD066203 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic analysis of the neonatal forebrain of FMR1 mutant marmosets
Description	Fragile X syndrome (FXS) is a monogenic cause of intellectual disability, developmental delay, and autism spectrum disorder (ASD), estimated to occur in 1 in 5,000 males and 1 in 4,000 to 1 in 8,000 females. It is caused by a CGG trinucleotide repeat expansion in the 5’ untranslated region of the fragile X messenger ribonucleoprotein 1 (FMR1) gene located at Xq27.3. A full mutation, greater than 200 CGG repeats, leads to silencing of the FMR1 gene and consequent loss of its product, the fragile X messenger ribonucleoprotein (FMRP). We generated FMR1 mutant common marmosets (Callithrix jacchus) using the CRISPR/Cas9 system and performed proteomic analysis of their neonatal forebrains to identify molecular changes associated with FMR1 deficiency. We analyzed samples from two wild-type (WT) and two FMR1 mutant marmosets.
HostingRepository	jPOST
AnnounceDate	2025-07-16
AnnouncementXML	Submission_2025-07-16_03:55:03.641.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Maria Harbers
SpeciesList	scientific name: Callithrix jacchus; NCBI TaxID: 9483;
ModificationList	S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide; alpha-amino acetylated residue
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-16 03:54:59	ID requested
⏵ 1	2025-07-16 03:55:04	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: marmoset, brain

submitter keyword: marmoset, brain

Contact List

Atsu Aiba
lab head
Maria Harbers
contact affiliation	The University of Tokyo
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003941/