PXD066193

PXD066193 is an original dataset announced via ProteomeXchange.

Title	Ex vivo lung perfusion enhances donor lung preservation in mice via Hippo signaling activation
Description	Background: Ex vivo lung perfusion (EVLP) is a promising technique that allows organ preservation and repair, increasing the number of marginal donor lungs for lung transplantation. This study aimed to establish an EVLP model in mice, and to unveil the molecular mechanisms responsible of EVLP beneficial effects. Methods: The mouse EVLP system was established, and mouse lungs were exposed to: (1) without ischemia or EVLP (control), (2) 45 min EVLP followed by 135 min cold ischemia (EVLP-CI), (3) 135 min cold ischemia followed by 45 min EVLP (CI-EVLP), and (4) 180 min cold ischemia (CI). At the end of the 3-hour lung preservation period, lungs were collected for proteomic profiling.
HostingRepository	iProX
AnnounceDate	2025-07-16
AnnouncementXML	Submission_2025-07-16_00:25:17.835.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhiwang Zhao
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-16 00:24:11	ID requested
⏵ 1	2025-07-16 00:25:18	announced

Dataset with its publication pending

submitter keyword: Ex vivo lung perfusion, mus msculus

Tian Jiang
contact affiliation	Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
contact email	jiangt19@fudan.edu.cn
lab head
Zhiwang Zhao
contact affiliation	Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
contact email	19301050219@fudan.edu.cn
dataset submitter

iProX dataset URI