PXD066188
PXD066188 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Elucidating the Fatty Acid Specificity Profile for Protein S-Acylation in cthrough Chemical Proteomics |
| Description | S-acylation is a crucial post-translational modification that transfers long-chain fatty acids to cysteine residues within proteins, but the fatty acid specificity of this modification in plants remains entirely unknown. In this study, we established a robust system for characterizing the fatty acid specificity of protein S-acylation in plant cells via click chemistry. We applied this approach to identify various S-acylated proteins modified by myristic acid, palmitic acid, or stearic acid in Arabidopsis through chemical proteomics. Additionally, we investigated the preferences for different fatty acid chain lengths among 24 protein S-acyltransferases and examined how elevated temperatures influence the utilization of stearic acid. Functional analyses indicated that specific fatty acids regulate the distribution of protein substrates across distinct membrane regions. Our current research will pave the way for advancements in the field of plant protein S-acylation, providing a powerful tool and valuable resource for future studies involving Arabidopsis and other plant species. |
| HostingRepository | iProX |
| AnnounceDate | 2025-07-16 |
| AnnouncementXML | Submission_2025-07-15_20:10:46.304.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Wenyang Zhang |
| SpeciesList | scientific name: Arabidopsis thaliana; NCBI TaxID: 3702; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-07-15 20:09:58 | ID requested | |
| ⏵ 1 | 2025-07-15 20:10:46 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: S-Acylation |
Contact List
| Jianbin Lai | |
|---|---|
| contact affiliation | South China Normal University |
| contact email | 20141062@m.scnu.edu.cn |
| lab head | |
| Wenyang Zhang | |
| contact affiliation | Guangdong Academy of Agricultural Sciences |
| contact email | zhangwenyang@mails.ccnu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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