PXD066169

PXD066169 is an original dataset announced via ProteomeXchange.

Title	StBPA1 attenuates surface receptor activation and contributes to immune responses against bacteria and oomycete pathogens in potato
Description	Plants utilize plasma-membrane-localized pattern recognition receptors (PRRs) to sense and respond to microbial infections. The downstream regulatory components have been studied extensively, but the mechanisms ensuring appropriate immune responses to diverse pathogens remain enigmatic. We report that a core regulatory component named StBPA1 (BINDING PARTNER OF ACD11-1) is a molecular switch that controls both anti-bacterial and anti-oomycete immunity. StBPA1-knockout displays dwarfed growth, enhanced pattern-triggered immunity (PTI), and broad-spectrum resistance to potato bacterial wilt and late blight diseases. StBPA1 negatively regulates the StFLS2-StBAK1/StSOBIR1-StBAK1 immune complex formation and inhibits StFLS2 kinase activity to prevent constitutive immune responses. In turn, StBAK1 specifically phosphorylates StBPA1 at Thr193/Ser195. This modification is enhanced by flg22/INF1 perception and impairs the negative regulatory role of StBPA1, thereby ensuring proper immune signaling. These findings identify an StBPA1-PRR complex regulatory module and highlight inhibitions by StBPA1 as key mechanisms to ensure efficient yet strictly regulated immune responses against different pathogens. Note: StBPA2 in this dataset was later renamed StBPA1 in follow-up experiments and publications.
HostingRepository	PRIDE
AnnounceDate	2025-07-15
AnnouncementXML	Submission_2025-07-15_07:28:16.138.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jie Li
SpeciesList	scientific name: Solanum tuberosum (Potato); NCBI TaxID: 4113;
ModificationList	phosphorylated residue; monohydroxylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-15 07:16:21	ID requested
⏵ 1	2025-07-15 07:28:16	announced

Dataset with its publication pending

submitter keyword: immune regulatory components, PAMP-triggered immunity (PTI), pattern recognition receptors (PRRs), StBPA1, potato disease resistance, phosphorylation

Xiaodan Wang
contact affiliation	College of Plant Protection, China Agricultural University, Beijing 100193, China
contact email	lijie9610@163.com
lab head
Jie Li
contact affiliation	China Agricultural University
contact email	lijie9610@163.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD066169
     1. Label: PRIDE project
     2. Name: StBPA1 attenuates surface receptor activation and contributes to immune responses against bacteria and oomycete pathogens in potato