PXD066148

PXD066148 is an original dataset announced via ProteomeXchange.

Title	Deciphering Radiopharmaceutical Mechanisms Through Integrated Proteomic and PTMs-proteomic Profiling
Description	Drug-regulated protein post-translational modifications (PTMs) enable the identification of modulated pathways and the revealing of phenotypic responses for the disease. However, the integrated regulatory mechanisms of radiopharmaceuticals across proteomic and PTMs landscapes remain poorly characterized. To address this gap, this study presents a quantitative multi-level proteomic analysis to assess regulated PTMs and pathway engagement. Quantitative glycoproteomics, phosphoproteomics, and global proteomics were performed using tumor tissues from radiopharmaceutical-treated mouse models. By analyzing the subcellular signaling pathways with site-specific PTMs, differentially expressed molecular signatures were identified with radiopharmaceutical action. Our study provides comprehensive landscape of the global proteome and PTMs-proteome for radiopharmaceuticals regulation. These findings uncover multi-level cellular molecular mechanisms involving DNA repair, extracellular matrix organization, and metabolic regulation. These findings elucidate the molecular mechanism of radiopharmaceuticals at the proteomic and PTMs-proteomic levels, offering valuable insights for radiopharmaceutical development.
HostingRepository	iProX
AnnounceDate	2025-07-14
AnnouncementXML	Submission_2025-07-15_01:09:56.317.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xuefang Dong
SpeciesList	scientific name: Mus ; NCBI TaxID: 10088;
ModificationList	N-glycosylated residue; phosphorylated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-15 01:09:31	ID requested
⏵ 1	2025-07-15 01:09:56	announced

Dataset with its publication pending

submitter keyword: radiopharmaceutical, glycoproteomics, phosphoproteomics, proteomics, molecular mechanism

Xiuling Li
contact affiliation	Dalian Institute of Chemical Physics
contact email	lixiuling@dicp.ac.cn
lab head
Xuefang Dong
contact affiliation	Dalian Institute of Chemical Physics
contact email	dongxuefang@dicp.ac.cn
dataset submitter

iProX dataset URI