PXD066108

PXD066108 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	A proteomics data of 30 tissues in aging female rhesus macaques (Macaca mulatta)
Description	A systematic investigation of aging patterns across virtually all major tissues in non-human primates, our evolutionarily closest relatives, can provide valuable insights into tissue aging in humans, which is still elusive largely due to the difficulty in sampling. Here, we generated and analyzed multi-omics data, including transcriptome, proteome, and metabolome, from 30 tissues of 17 female rhesus macaques (Macaca mulatta) aged 3 to 27 years. We found that certain molecular features, such as increased inflammation, are consistent across tissues and align with findings in mice and humans. We further revealed that tissue aging in macaques is asynchronous and can be classified into two distinct types, with one type exhibiting more pronounced aging degree, likely associated with decreased mRNA translation efficiency, and predominantly contributing to whole-body aging. This work provides a comprehensive molecular landscape of aging in non-human primate tissues and links translation efficiency to tissue-specific aging.
HostingRepository	PRIDE
AnnounceDate	2025-11-06
AnnouncementXML	Submission_2025-11-05_19:19:54.799.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gong-Hua Li
SpeciesList	scientific name: Macaca mulatta (Rhesus macaque); NCBI TaxID: NEWT:9544;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-14 13:24:40	ID requested
⏵ 1	2025-11-05 19:19:55	announced

Publication List

10.1038/S41592-025-02912-Y;

10.1038/S41592-025-02912-Y;

Keyword List

submitter keyword: Proteomics
Tissue aging
Rhesus macaques
LC-MS
DIA

submitter keyword: Proteomics

Tissue aging

Rhesus macaques

LC-MS

DIA

Contact List

Qing-Peng Kong
contact affiliation	State Key Laboratory of Genetic Evolution & Animal Models,Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China.
contact email	kongqp@mail.kiz.ac.cn
lab head
Gong-Hua Li
contact affiliation	Kunming Institute of Zoology, Chinese Academy of Sciences
contact email	ligonghua@mail.kiz.ac.cn
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD066108
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD066108

PRIDE project URI

Repository Record List

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