PXD066092 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | TET1 Functions as a Tumor Suppressor in Lung Adenocarcinoma Through Epigenetic Remodeling and Immune Modulation. |
| Description | TET genes have been characterized as tumor suppressors because their expression levels are reduced in many human cancers including lymphoma, prostate, and pancreas, and TET2 gene mutations are common in hematological cancers. In contrast, TET1 was recently reported to be overexpressed in triple negative breast cancer and to act as a protooncogene in lung cancer. In our study, TET1 knock out and overexpressed H441 cells were isolated for multi-omics analyses. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-23 |
| AnnouncementXML | Submission_2026-01-23_01:53:33.555.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Monica Kruk |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-07-13 10:23:22 | ID requested | |
| ⏵ 1 | 2026-01-23 01:53:34 | announced | |
Publication List
| 10.1186/s13072-025-00617-2; |
| Rahim A, Ruis BL, Rajczewski AT, Kruk ME, Tretyakova NY, TET1 functions as a tumor suppressor in lung adenocarcinoma through epigenetic remodeling and immune modulation. Epigenetics Chromatin, 18(1):53(2025) [pubmed] |
Keyword List
| submitter keyword: 3D spheroid, tumor suppressor gene,TET1, DNA methylation, lung cancer |
Contact List
| Natalia Y. Tretyakova |
|---|
| contact affiliation | Natalia Y. Tretyakova, Department of Medicinal Chemistry, College of Pharmacy, and the Masonic Cancer Center, University of Minnesota-Twin Cities, Minneapolis, MN, 55455, USA |
| contact email | trety001@umn.edu |
| lab head | |
| Monica Kruk |
|---|
| contact affiliation | UMN |
| contact email | joh15006@umn.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD066092 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD066092
- Label: PRIDE project
- Name: TET1 Functions as a Tumor Suppressor in Lung Adenocarcinoma Through Epigenetic Remodeling and Immune Modulation.
