⮝ Full datasets listing
PXD066040
PXD066040 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A transgenic mouse allows characterisation of the HLA-C*06:02 immunopeptidome in a model of psoriasis |
| Description | Psoriasis vulgaris is a T cell-mediated autoimmune skin condition affecting around one in fifty people worldwide. Whilst advanced immunomodulatory therapeutic options have become available in recent years, ongoing disease suppression is still required with no curative treatment available to date. The human leukocyte antigen class I allele HLA-C*06:02 is the main genetic risk determinant of psoriasis. HLA-C molecules present peptide antigens to CD8 T cells and natural killer cells that in turn elicit and perpetuate the immune response, yet little is known about the ligands presented by HLA-C*06:02. To gain an understanding of which HLA-C*06:02-restricted peptides are presented by epidermal cell populations and might be initiators of the autoimmune response in psoriasis, we have conducted an in depth immunopeptidomic analysis of HLA-C*06:02 keratinocyte and melanocyte cell lines. Furthermore, we introduce a HLA-C*06:02 transgenic mouse which, in conjunction with the imiquimod model of psoriasis, allowed us to assess the ex vivo immunopeptidome of HLA-C*06:02 in psoriasiform skin. Overall, we identified 20,812 high confidence HLA-C*06:02 bound peptide ligands. Thus, we present a comprehensive HLA-C in vitro immunopeptidomic dataset and the first HLA-C*06:02 ex vivo dataset of psoriasis-relevant peptide antigens that may inform the development of novel antigen-specific, curative therapeutic approaches in psoriasis. |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-12-14 |
| AnnouncementXML | Submission_2025-12-14_18:34:09.636.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | A. Braun |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | N-acetylated residue; Oxidation; Deamidated |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-07-10 20:33:37 | ID requested | |
| ⏵ 1 | 2025-12-14 18:34:10 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: immunopeptidomics, immunopeptidome, major histocompatibility complex, HLA-C*06:02, MHC class I, MHC class II, DatasetType:Other (immunopeptidomics) |
Contact List
| Anthony Purcell | |
|---|---|
| contact affiliation | Monash University |
| contact email | anthony.purcell@monash.edu |
| lab head | |
| A. Braun | |
| contact affiliation | Monash |
| contact email | assolbraun@web.de |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v10/MSV000098479/ |
