PXD066004

PXD066004 is an original dataset announced via ProteomeXchange.

Title	In vitro host-parasite models combined with proteomics reveal cell type-specific responses of early-migrating Fasciola hepatica juveniles
Description	The project employs two complementary in vitro models combined with quantitative proteomics to study host-parasite interactions involving Fasciola hepatica newly excysted juveniles. The single cell type (SiCT) model uses SWATH-MS to analyse interactions with mesothelial and hepatic stellate cells, while the sequential cell type (SeCT) model applies diaPASEF to study successive encounters with intestinal epithelial and mesothelial cells. Proteomic data were processed with DIA-NN and analysed through validated pipelines to characterise differential protein expression associated with distinct host cell interactions.
HostingRepository	PRIDE
AnnounceDate	2026-03-02
AnnouncementXML	Submission_2026-03-02_03:12:52.401.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marta López-García
SpeciesList	scientific name: Fasciola hepatica (Liver fluke); NCBI TaxID: NEWT:6192; scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF fleX; TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-10 05:36:30	ID requested
⏵ 1	2026-03-02 03:12:52	announced

10.1016/J.MCPRO.2026.101543;

submitter keyword: None

Mar Siles
contact affiliation	Laboratory of Helminth Parasites of Zoonotic Importance(ATENEA), Institute of Natural Resources and Agrobiology of Salamanca (IRNASA-CSIC), Spain (lab head)
contact email	mmar.siles@irnasa.csic.es
lab head
Marta López-García
contact affiliation	Laboratory of Helminth Parasites of Zoonotic Importance (ATENEA), Institute of Natural Resources and Agrobiology of Salamanca (IRNASA-CSIC), C/Cordel de Merinas 40-52, 37008 Salamanca, Spain
contact email	marta.lopez@irnasa.csic.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD066004

PRIDE project URI

• PRIDE
  1. PXD066004
     1. Label: PRIDE project
     2. Name: In vitro host-parasite models combined with proteomics reveal cell type-specific responses of early-migrating Fasciola hepatica juveniles