⮝ Full datasets listing
PXD065981
PXD065981 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | IKKβ and USP28 govern HEY1 stability to enhance cancer stemness and immune evasion in hepatocellular carcinoma |
| Description | Our study substantially advances the field by resolving a critical gap in understanding HEY1 regulation. Building on evidence that HEY1 undergoes ubiquitination during liver CSC differentiation, we elucidate how USP28 governs HEY1 protein stability-revealing novel mechanistic insights into immune evasion. Furthermore, our results demonstrate compelling clinical relevance: targeting excessive HEY1 stability via USP28 inhibition combined with PD-1 blockade represents a promising therapeutic strategy against HCC and other HEY1-driven malignancies. |
| HostingRepository | iProX |
| AnnounceDate | 2025-11-27 |
| AnnouncementXML | Submission_2025-11-27_19:50:30.305.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xu Huang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-07-09 22:39:15 | ID requested | |
| ⏵ 1 | 2025-11-27 19:50:30 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: IKKβ, USP28, HEY1, hepatocellular carcinoma |
Contact List
| Chungang Liu | |
|---|---|
| contact affiliation | The Second Affiliated Hospital, Chongqing Medical University |
| contact email | liuchungang@zju.edu.cn |
| lab head | |
| Xu Huang | |
| contact affiliation | The Second Affiliated Hospital of Chongqing Medical University |
| contact email | 1481227172@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
