⮝ Full datasets listing
PXD065974
PXD065974 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic and phosphoproteomic profiling of IRI-induced AKI-to-CKD progression |
| Description | Acute kidney injury (AKI), a condition marked by rapid loss of kidney function, carries significant morbidity and often progresses to chronic kidney disease (CKD). Ischemia-reperfusion injury (IRI) is a major pathogenic driver of AKI. To elucidate the molecular mechanisms underlying IRI-induced AKI and its progression to CKD, we performed comprehensive proteomic and phosphoproteomic profiling of kidney tissues. Using high-resolution mass spectrometry, we confidently quantified over 7,500 proteins and 4,400 non-redundant phosphoproteins, providing a systems-level view of the extensively remodeled kidney proteome and phosphoproteome post-IRI. Our dataset reveals dynamic alterations in key signaling pathways associated with AKI-to-CKD transition, offering unprecedented molecular insights into disease progression. This resource will facilitate the discovery of therapeutic targets to mitigate IRI-induced kidney damage and its chronic sequelae. |
| HostingRepository | iProX |
| AnnounceDate | 2025-07-10 |
| AnnouncementXML | Submission_2026-01-18_17:55:11.831.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Shaowu Zhang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | phosphorylated residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-07-09 20:51:00 | ID requested | |
| ⏵ 1 | 2026-01-18 17:55:12 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Proteomics, Phosphoproteomics, Ischemia-reperfusion injury (IRI), Acute kidney injury (AKI), Chronic kidney disease (CKD) |
Contact List
| Huafeng Liu | |
|---|---|
| contact affiliation | Affiliated Hospital of Guangdong Medical University |
| contact email | liuhf@gdmu.edu.cn |
| lab head | |
| Shaowu Zhang | |
| contact affiliation | Affiliated Hospital of Guangdong Medical University |
| contact email | 450036449@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
