PXD065952

PXD065952 is an original dataset announced via ProteomeXchange.

Title	Mkrn3 binds Gnrh1 mRNA to alter subcellular localization of the Gnrh1 precursor protein - Mkrn3-AP-MS
Description	Loss-of-function mutations in MKRN3 cause central precocious puberty, and our findings show that MKRN3 regulates GnRH production by binding the Gnrh1 3′UTR and altering subcellular localization of its precursor protein through post-transcriptional mechanisms. This function likely involves interactions with RNA-binding proteins such as IGF2BP2 and may extend to other cell types and neuropeptides. This is work is for the affinity purification mass spectrometry (AP-MS)of MKRN3
HostingRepository	PRIDE
AnnounceDate	2026-05-14
AnnouncementXML	Submission_2026-05-14_05:52:15.969.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Oded Kleifeld
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	ubiquitination signature dipeptidyl lysine; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-09 08:38:10	ID requested
⏵ 1	2026-05-14 05:52:16	announced

Dataset with its publication pending

submitter keyword: AP-MS,Mkrn3, Gnrh1 precursor protein

Philippa Melamed
contact affiliation	The Dr. Irving and Jeanette Benveniste Chair in Life Sciences, Faculty of Biology, Technion-Israel Institute of Technology, Haifa 32000 ISRAEL
contact email	philippa@technion.ac.il
lab head
Oded Kleifeld
contact affiliation	Technion
contact email	okleifeld@technion.ac.il
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD065952

PRIDE project URI

• PRIDE
  1. PXD065952
     1. Label: PRIDE project
     2. Name: Mkrn3 binds Gnrh1 mRNA to alter subcellular localization of the Gnrh1 precursor protein - Mkrn3-AP-MS