PXD065951 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic analysis of cervicovaginal fluid for endometriosis biomarker discovery |
| Description | Endometriosis is a gynaecological disease facing significant diagnostic challenges, contributing to an extensive diagnostic delay. Non-invasive diagnostic biomarkers of endometriosis could expedite diagnosis and minimise the reliance on surgery to confirm endometriosis. This pilot study aimed to identify candidate protein biomarkers of endometriosis from cervicovaginal fluid i) collected from consenting people having surgery for suspected endometriosis and ii) sampled via low vaginal swab. Samples from people with (n=20) and without (n=19) endometriosis across were analysed by data independent acquisition mass spectrometry using the Sequential Window Acquisition of All Theoretical Mass Spectra (SWATH)-MS approach. Samples were measured and analysed in two experimental runs (E1 and E2) based on time periods of sample collection. ELISA was performed to validate SWATH-MS findings. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-06 |
| AnnouncementXML | Submission_2026-04-06_06:40:24.793.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Torsten Kleffmann |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
| Instrument | TripleTOF 5600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-07-09 08:32:50 | ID requested | |
| ⏵ 1 | 2026-04-06 06:40:25 | announced | |
Publication List
| Paterson ESJ, Scheck S, Kleffmann T, Gill R, Bedford N, McDowell S, Girling JE, Henry CE, Proteomic Analysis of Cervicovaginal Fluid for Diagnostic Endometriosis Biomarker Discovery. Proteomics Clin Appl, 20(3):e70044(2026) [pubmed] |
| 10.1002/prca.70044; |
Keyword List
| submitter keyword: cervicovaginal fluid, endometriosis, SWATH-MS |
Contact List
| Claire Henry |
|---|
| contact affiliation | Department of Surgery and Anaesthesia, University of Otago (Wellington) |
| contact email | claire.henry@otago.ac.nz |
| lab head | |
| Torsten Kleffmann |
|---|
| contact affiliation | Department of Biochemistry, University of Otago |
| contact email | torsten.kleffmann@otago.ac.nz |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065951 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD065951
- Label: PRIDE project
- Name: Proteomic analysis of cervicovaginal fluid for endometriosis biomarker discovery
