PXD065950 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identification of a highly sensitive combination of protein biomarkers for the detection of high-grade bladder cancer |
| Description | Bladder cancer is the fifth most common malignancy worldwide and presents a significant diagnostic challenge due to its high recurrence rate and reliance on invasive detection methods such as cystoscopy. Current diagnostic tools, including cytology, have limited sensitivity. This study aims to identify urinary protein biomarkers that can serve as a non-invasive diagnostic tool for high-risk bladder cancer. We utilized mass spectrometry-based proteomic analysis to evaluate urinary samples from bladder cancer patients and control individuals. A combination of four protein biomarkers—Complement Factor H (CFH), Fibrinogen β (FGB), Alpha-2-macroglobulin (A2M), and Alpha-amylase pancréatique (AMY2A)—was identified as a promising diagnostic panel. These biomarkers demonstrated 100% sensitivity for detecting high-grade tumors, with a false-positive rate of 70-80%, depending on patient history. Comparative analysis with traditional cytology revealed superior sensitivity and potential for early-stage detection. These findings highlight the feasibility of a urinary proteomic approach in bladder cancer diagnosis using a combination of protein biomarkers, and provide a foundation for the development of a clinically viable, cost-effective, and less invasive screening method. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-07 |
| AnnouncementXML | Submission_2026-02-06_19:59:08.436.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Dominique Levesque |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | carbamoylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-07-09 08:19:28 | ID requested | |
| ⏵ 1 | 2026-02-06 19:59:08 | announced | |
Publication List
Keyword List
| submitter keyword: proteomics, mass spectrometry,bladder cancer, non-invasive diagnostics, early detection, urinary biomarkers |
Contact List
| Francois-Michel Boisvert |
|---|
| contact affiliation | Department of Immunology and Cell biology, Université de Sherbrooke, 3201, Jean-Mignault, Sherbrooke, Québec, J1E 4K8, Canada |
| contact email | fm.boisvert@usherbrooke.ca |
| lab head | |
| Dominique Levesque |
|---|
| contact affiliation | University of Sherbrooke, FM Boisvert lab |
| contact email | dominique.levesque@usherbrooke.ca |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD065950 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD065950
- Label: PRIDE project
- Name: Identification of a highly sensitive combination of protein biomarkers for the detection of high-grade bladder cancer
