PXD065892

PXD065892 is an original dataset announced via ProteomeXchange.

Title	Diagnostics of autoimmune hepatitis enabled by non-invasive clinical proteomics
Description	Autoimmune hepatitis (AIH) can be challenging to distinguish from other chronic liver diseases such as metabolic dysfunction-associated steatotic liver disease (MASLD). We applied advanced proteomic analysis to paired liver and plasma samples from newly diagnosed AIH patients, MASLD patients, and healthy controls to uncover disease-specific pathways and biomarkers. We quantified 7632 liver and 556 plasma proteins, identifying significant differences in 2521 liver and 227 plasma proteins between AIH and healthy individuals. A machine learning model based on plasma proteomics accurately distinguished AIH from MASLD and healthy controls (AUC = 0.91), with validation in the UK Biobank confirming diagnostic value for several candidate biomarkers. This study highlights distinct metabolic and immune signatures in AIH and supports the utility of plasma proteomics in non-invasive disease classification.
HostingRepository	PRIDE
AnnounceDate	2025-07-18
AnnouncementXML	Submission_2025-07-17_17:38:37.107.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Annelaura Bach Nielsen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-08 04:20:35	ID requested
⏵ 1	2025-07-17 17:38:37	announced

10.1111/APT.70273;

submitter keyword: Human, Plasma, Liver, AIH

Nicolai Jacob Wewer Albrechtsen
contact affiliation	Department of clinical Biochemistry, Copenhagen University Hospital, Bispebjerg and Frederiksberg Hospital, Denmark
contact email	nicolai.albrechtsen@regionh.dk
lab head
Annelaura Bach Nielsen
contact affiliation	University of Copenhagen
contact email	annelaura@live.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD065892

PRIDE project URI

• PRIDE
  1. PXD065892
     1. Label: PRIDE project
     2. Name: Diagnostics of autoimmune hepatitis enabled by non-invasive clinical proteomics