PXD065889 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | DNA Polymerase Alpha Catalytic Subunit A interactome |
| Description | Replication origin under-licensing extends S phase and leads to mitotic entry before S-phase completion. At mitotic entry, M-CDKs phosphorylate DNA Pol, leading to its eviction from chromatin, which activates the DNA Damage Checkpoint. This provides time to complete DNA synthesis by MiDAS at the expense of genome stability. Pol1 and Pol1-Cdk13A interactomes were analyzed during S phase and mitosis in a context of an extended S phase. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-10 |
| AnnouncementXML | Submission_2026-09-10_04:29:14.049.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD065889 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Functional Proteomics Platform FPP |
| SpeciesList | scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: NEWT:4932; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-07-08 03:33:15 | ID requested | |
| ⏵ 1 | 2026-09-10 04:29:14 | announced | |
Publication List
Keyword List
| submitter keyword: MiDAS,DNA polymerase a, Saccharomyces cerevisiae, phosphorylation, Pol1, M-CDK phosphosites, Cell cycle, genome stability, Extended S phase, DNA replication |
Contact List
| Etienne Schwob |
|---|
| contact affiliation | IGMM, CNRS, Univ Montpellier, Montpellier, France |
| contact email | etienne.schwob@igmm.cnrs.fr |
| lab head | |
| Functional Proteomics Platform FPP |
|---|
| contact affiliation | FPP CNRS |
| contact email | contact@fpp.cnrs.fr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD065889 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD065889
- Label: PRIDE project
- Name: DNA Polymerase Alpha Catalytic Subunit A interactome
