PXD065824

PXD065824 is an original dataset announced via ProteomeXchange.

Title	Target profiling of organoplatinum(II) complex reveals role of protein tyrosine phosphatase 1B in modulating immunogenicity
Description	Immunogenic cell death (ICD) inducers are valuable chemotherapeutic agents that elicit protective immune responses against tumors. However, the specific molecular targets directly associated with ICD remain less explored. Here, a Type II ICD inducer, Pt-ER, was validated as a bona fide ICD inducer with the ability to establish protection against colorectal cancer. Based on Pt-ER, several ICD-inducing photoactivable probes were designed to capture their potential targets. By integrating quantitative proteomics analysis, genetic method and biochemical assays, we identified that PTP1B is a direct target of Pt-ER and engages in ICD.
HostingRepository	PRIDE
AnnounceDate	2026-02-02
AnnouncementXML	Submission_2026-02-01_16:13:31.049.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiao Xia Zou
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-06 22:20:30	ID requested
⏵ 1	2026-02-01 16:13:32	announced

Zou JX, Ivanov-Rostovtsev PA, Arakelyan J, Babak MV, Ang WH, Organoplatinum(II) Type II Immunogenic Cell Death Inducers Target Protein Tyrosine Phosphatase 1B to Drive Immunogenicity. J Am Chem Soc, 148(2):2660-2672(2026) [pubmed]

10.1021/jacs.5c18904;

submitter keyword: immunogenicity modulation,Target identification, immunogenic cell death, chemoproteomics, protein tyrosine phosphatase 1B

Wee Han Ang
contact affiliation	Department of Chemistry, National University of Singapore
contact email	ang.weehan@nus.edu.sg
lab head
Jiao Xia Zou
contact affiliation	National University of Singapore
contact email	e0669600@u.nus.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD065824

PRIDE project URI

• PRIDE
  1. PXD065824
     1. Label: PRIDE project
     2. Name: Target profiling of organoplatinum(II) complex reveals role of protein tyrosine phosphatase 1B in modulating immunogenicity