PXD065775

PXD065775 is an original dataset announced via ProteomeXchange.

Title	Proteomic signatures in distant normal tissues demonstrate superior predictive value for hepatocellular carcinoma recurrence
Description	To investigate the molecular signatures associated with hepatocellular carcinoma (HCC) recurrence, we conducted a comprehensive proteomic analysis using clinical samples, including adjacent normal tissues (ANTs), primary tumor tissues (PTTs), and distant normal tissues (DNTs) (n=8 per group). These samples were processed using isobaric tags for relative and absolute quantitation (iTRAQ)-based quantitative proteomics, enabling high-throughput and accurate comparison of protein expression profiles across different tissue types. By systematically analyzing the proteomic differences between ANTs, PTTs, and DNTs, we aimed to identify tissue-specific biomarkers and dysregulated pathways that may contribute to HCC pathogenesis and recurrence. Our findings highlight the unique proteomic signatures of DNTs, which demonstrate superior predictive value for HCC recurrence compared to conventional tumor-centric approaches. This study provides novel insights into the role of distal microenvironmental changes in cancer progression and offers potential biomarkers for improved prognostic assessment.
HostingRepository	PRIDE
AnnounceDate	2025-11-25
AnnouncementXML	Submission_2025-11-24_20:49:08.780.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jingzi Zhang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-03 23:59:58	ID requested
⏵ 1	2025-11-24 20:49:09	announced

Dataset with its publication pending

submitter keyword: Human, HCC recurrence, liver

Zhang Jingzi
contact affiliation	Nanjing University
contact email	zhangjingzi@nju.edu.cn
lab head
Jingzi Zhang
contact affiliation	Medical School of Nanjing University
contact email	zhangjingzi@nju.edu.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD065775
     1. Label: PRIDE project
     2. Name: Proteomic signatures in distant normal tissues demonstrate superior predictive value for hepatocellular carcinoma recurrence