PXD065687 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Shiga toxin-positive extracellular vesicles induce higher mortality and more kidney injury than free toxin |
| Description | Escherichia coli O157:H7 is a non-invasive Shiga toxin (Stx)-producing pathogen that causes gastroenteritis and hemolytic uremic syndrome characterized by acute kidney injury. Stx binding to cells induces release of extracellular vesicles (EVs) containing the toxin. This study aimed to demonstrate the lethal effects of toxin-positive vesicles compared to free toxin, and the importance of the Stx receptor, globotriaosylceramide (Gb3), for these effects. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-23 |
| AnnouncementXML | Submission_2026-06-23_06:09:03.471.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Markus Wendler |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | acetylated residue |
| Instrument | maXis |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-07-02 07:39:02 | ID requested | |
| ⏵ 1 | 2026-06-23 06:09:03 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: globotriaosylceramide,Shiga toxin 2, Extracellular vesicles |
Contact List
| Diana Karpman |
|---|
| contact affiliation | Department of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden |
| contact email | diana.karpman@med.lu.se |
| lab head | |
| Markus Wendler |
|---|
| contact affiliation | Lund University |
| contact email | markus.wendler@med.lu.se |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD065687 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD065687
- Label: PRIDE project
- Name: Shiga toxin-positive extracellular vesicles induce higher mortality and more kidney injury than free toxin
