PXD065631

PXD065631 is an original dataset announced via ProteomeXchange.

Title	Combination Therapy with Nisin, Urolithin B, and Vincristine Exhibits Synergistic Antiproliferative and Pro-Apoptotic Effects Against Human Lymphoma Cells: Evidence From Proteomics
Description	This study investigates the synergistic antitumor efficacy of a triple combination therapy—Nisin (N), Urolithin B (UB), and Vincristine (Vinc)—against human HBK11 lymphoma cells, with an emphasis on proteomic mechanisms of action. The findings elucidate the molecular underpinnings of this novel combination and underscore the potential of postbiotics as adjuvants to conventional chemotherapy, offering a mechanistically informed strategy for improved lymphoma treatment.
HostingRepository	PRIDE
AnnounceDate	2025-09-20
AnnouncementXML	Submission_2025-09-19_16:14:10.280.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Muhammad Alsherbiny
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-30 21:39:13	ID requested
⏵ 1	2025-09-19 16:14:10	announced

10.3389/FIMMU.2025.1664468;

submitter keyword: Vincristine, Urolithin B, Synergy, Apoptosis, Nisin, Proteomics,Lymphoma

Deep Bhuyan
contact affiliation	NICM Health Research Institute, Western Sydney University
contact email	D.bhuyan@westernsydney.edu.au
lab head
Muhammad Alsherbiny
contact affiliation	1) Freedman Foundation Metabolomics Facility, Innovation Centre, Victor Chang Cardiac Research Institute UNSW 2) Pharmacognosy Department, Faculty of Pharmacy, Cairo University
contact email	muhammad.alsherbiny@pharma.cu.edu.eg
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD065631

PRIDE project URI

• PRIDE
  1. PXD065631
     1. Label: PRIDE project
     2. Name: Combination Therapy with Nisin, Urolithin B, and Vincristine Exhibits Synergistic Antiproliferative and Pro-Apoptotic Effects Against Human Lymphoma Cells: Evidence From Proteomics