PXD065529

PXD065529 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Inhibition of AhR improves cortical bone and skeletal muscle function via preservation of neuromuscular junctions
Description	This project aimed to assess the role of pharmacological inhibition of the aryl hydrocarbon receptor (AhR) on skeletal muscle and cortical bone health in aged mice. As part of a broader systems biology approach, proteomic profiling was employed to investigate molecular mediators of neuromuscular junction (NMJ) function in skeletal muscle tissue. The study compared vehicle-treated versus BAY2416964-treated aged mice, revealing key differentially expressed proteins involved in axonal development and NMJ stability.
HostingRepository	PRIDE
AnnounceDate	2025-07-06
AnnouncementXML	Submission_2025-07-05_18:32:15.186.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wenbo Zhi
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-26 11:34:34	ID requested
⏵ 1	2025-07-05 18:32:15	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: LC-MSMS
aryl hydrocarbon receptor
proteomics

submitter keyword: LC-MSMS

aryl hydrocarbon receptor

proteomics

Contact List

McGee Lawrence, Meghan
contact affiliation	Department Chair • MCG - Department of Cellular Biology & Anatomy, Augusta University
contact email	mmcgeelawrence@augusta.edu
lab head
Wenbo Zhi
contact affiliation	Augusta University
contact email	wzhi@augusta.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD065529
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD065529

PRIDE project URI

Repository Record List

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