PXD065503

PXD065503 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	SILAC E3 ligase activity-based profiling of interferon-stimulated THP-1 cells
Description	Activity-based probes that covalently label proteins with transthiolating E3 ligase activity were used to determine differential changes in E3 ligase activity upon interferon stimulation of monocytic THP-1 cells.
HostingRepository	PRIDE
AnnounceDate	2026-05-22
AnnouncementXML	Submission_2026-05-22_10:40:50.631.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Satpal Virdee
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-26 04:55:23	ID requested
⏵ 1	2026-05-22 10:40:51	announced

Publication List

Squair DR, Rivers E, Sowar H, Balci A, Harmo R, Wright DJ, Beniwal G, Soetens M, Mathur S, Tollervey A, Wood NT, Pao KC, Stanton C, Fletcher AJ, Virdee S, ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA. Mol Cell, 86(6):1164-1181.e12(2026) [pubmed]
10.1016/j.molcel.2026.02.015;

Squair DR, Rivers E, Sowar H, Balci A, Harmo R, Wright DJ, Beniwal G, Soetens M, Mathur S, Tollervey A, Wood NT, Pao KC, Stanton C, Fletcher AJ, Virdee S, ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA. Mol Cell, 86(6):1164-1181.e12(2026) [pubmed]

10.1016/j.molcel.2026.02.015;

Keyword List

submitter keyword: SILAC, Activity-based probes

submitter keyword: SILAC, Activity-based probes

Contact List

Satpal Virdee
contact affiliation	MRC Protein phosphorylation and ubiquitylation unit, University of Dundee
contact email	s.s.virdee@dundee.ac.uk
lab head
Satpal Virdee
contact affiliation	University of Dundee
contact email	s.s.virdee@dundee.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD065503
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD065503

PRIDE project URI

Repository Record List

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