PXD065419

PXD065419 is an original dataset announced via ProteomeXchange.

Title	SUMOylation proteomic analysis in mouse liver
Description	Protein SUMOylation is crucial in both physiological and pathological contexts, but its role in acute liver injury is poorly understood. We found that SENP3, a SUMO2/3 protease, rapidly accumulates in hepatocytes around the pericentral vein zone within 2 hours of CCl₄-induced liver injury in mice. Knockout of SENP3 in hepatocytes worsens liver damage and promotes pyroptosis. The project demonstrated that SENP3 inhibits hepatocyte pyroptosis through a finely tuned mechanism involving post-translational modifications and the stabilization of key biomolecules HNRNPL.
HostingRepository	PRIDE
AnnounceDate	2026-02-09
AnnouncementXML	Submission_2026-02-08_16:12:27.560.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jie Yang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	sumoylated lysine
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-24 21:57:56	ID requested
⏵ 1	2026-02-08 16:12:28	announced

10.1016/j.isci.2025.113067;

Xiong X, Zhi Y, Yang N, Zhao W, Wang S, Zhu H, Tang J, Yi J, Sun X, Yang J, SENP3 protects hepatocyte from pyroptosis during acute liver injury through deSUMOylation of HNRNPL. iScience, 28(8):113067(2025) [pubmed]

submitter keyword: SENP3,Protein SUMOylation, liver

Jie Yang
contact affiliation	1. Department of Biochemistry and Molecular Cell Biology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine.
contact email	yangjieyj@shsmu.edu.cn
lab head
Jie Yang
contact affiliation	Shanghai Jiao Tong University School of Medicine
contact email	yangjieyj@shsmu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD065419

PRIDE project URI

• PRIDE
  1. PXD065419
     1. Label: PRIDE project
     2. Name: SUMOylation proteomic analysis in mouse liver