PXD065385

PXD065385 is an original dataset announced via ProteomeXchange.

Title	Cornulin, a potential prognostic biomarker in head and neck squamous cell carcinoma, acts as an anti-tumour agent by inhibiting cell cycle through upregulation of p18.
Description	The xenograft models were developed using 4–6-week-old CD1-Foxn1nu nude male mice and subcutaneously inoculating HNSCC cell lines, i.e., Cal27. In each mouse, the left flank received Cal27 untreated cells and the right flank received Cal27 Cornulin-overexpressing cells to allow within-animal comparison. After tumor development, mice were sacrificed, and xenograft tumors were excised. Tumor tissues were then subjected to protein extraction, tryptic digestion, and LC-MS/MS-based proteomic analysis to identify differentially expressed proteins associated with Cornulin overexpression in vivo.
HostingRepository	PRIDE
AnnounceDate	2025-07-16
AnnouncementXML	Submission_2025-07-16_03:38:40.722.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Arnab Pal
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-24 02:37:54	ID requested
⏵ 1	2025-07-16 03:38:41	announced

Dataset with its publication pending

submitter keyword: Head and neck squamous cell carcinoma

Cornulin

Tumour differentiation

Prognosis

Salivary Biomarker

Cell cycle

Arnab Pal
contact affiliation	Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, India
contact email	pal.arnab@pgimer.edu.in
lab head
Arnab Pal
contact affiliation	Post Graduate Institute of Medical Education and Research
contact email	pal.arnab@pgimer.edu.in
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD065385

PRIDE project URI

• PRIDE
  1. PXD065385
     1. Label: PRIDE project
     2. Name: Cornulin, a potential prognostic biomarker in head and neck squamous cell carcinoma, acts as an anti-tumour agent by inhibiting cell cycle through upregulation of p18.