PXD065382

PXD065382 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic Analysis of the E6 Interactome in Response to Anisomelic Acid Treatment
Description	Human papillomavirus (HPV) is a well-known cause of cervical cancer, with the viral oncoprotein E6 playing a key role in carcinogenesis. We previously showed that anisomelic acid treatment reduces E6 protein levels in HPV-positive cancer cells. In this study, we used mass spectrometry-based proteomics to investigate how anisomelic acid affects the HPV16 E6 interactome in normal oral keratinocytes.
HostingRepository	PRIDE
AnnounceDate	2025-09-22
AnnouncementXML	Submission_2025-09-22_01:24:18.006.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michael Santos Silva
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-24 01:18:49	ID requested
⏵ 1	2025-09-22 01:24:18	announced

Publication List

10.1016/j.jprot.2025.105536;
Santos Silva M, Coelho-Rato LS, Delshad N, Tarkhova T, Edman J, Paul P, Meinander A, Eriksson JE, Anisomelic acid promotes proteasomal degradation of HPV16 E6 via E3 ligase recruitment: A mass spectrometry-based interactome study. J Proteomics, 322():105536(2025) [pubmed]

10.1016/j.jprot.2025.105536;

Santos Silva M, Coelho-Rato LS, Delshad N, Tarkhova T, Edman J, Paul P, Meinander A, Eriksson JE, Anisomelic acid promotes proteasomal degradation of HPV16 E6 via E3 ligase recruitment: A mass spectrometry-based interactome study. J Proteomics, 322():105536(2025) [pubmed]

Keyword List

submitter keyword: LC-MS/MS, Anisomelic acid, Normal oral keratinocytes, HPV16 E6

submitter keyword: LC-MS/MS, Anisomelic acid, Normal oral keratinocytes, HPV16 E6

Contact List

John Eriksson
contact affiliation	Åbo Akademi University, Faculty of Science and Engineering, Finland
contact email	john.eriksson@abo.fi
lab head
Michael Santos Silva
contact affiliation	Åbo Akademi University
contact email	msantoss@abo.fi
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD065382
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD065382

PRIDE project URI

Repository Record List

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