PXD065365

PXD065365 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	2E7 Antigen Identification Using PhAbomics Technology
Description	Antibody–drug conjugates (ADCs) require antibodies with both high specificity and efficient internalization—features often overlooked by conventional discovery pipelines that rely on preselected antigens and recombinant proteins. Here, we present an integrated phenotypic platform that combines target-unbiased live-cell biopanning with in situ chemical crosslinking and mass spectrometry to concurrently identify internalizing 49 antibodies and their membrane-bound cognate antigens in a physiologic context.
HostingRepository	PRIDE
AnnounceDate	2025-11-20
AnnouncementXML	Submission_2025-11-20_01:48:14.907.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD065365
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Eugene YI
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-23 20:08:20	ID requested
⏵ 1	2025-11-20 01:48:15	announced

Publication List

10.6019/PXD065365;

10.6019/PXD065365;

Keyword List

submitter keyword: Antibody, Antigen, Cell-based Antibody Panning

submitter keyword: Antibody, Antigen, Cell-based Antibody Panning

Contact List

Eugene C
contact affiliation	Seoul National University
contact email	euyi@snu.ac.kr
lab head
Eugene YI
contact affiliation	Seoul National University
contact email	tcpl.mmbs@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD065365
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD065365

PRIDE project URI

Repository Record List

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